US 7,432,391 B2
	Process for the production of tert-butyl N-(2-bromoethyl)carbamate
Makoto Momomoto, Osaka (Japan); Yoshiaki Suzuki, Osaka (Japan); Minoru Yamagami, Osaka (Japan); Keisuke Matsumoto, Osaka (Japan); and Yusuke Sakaguchi, Osaka (Japan)
Assigned to Daito Chemix Corporation, Osaka (Japan)
Appl. No. 11/795,025 PCT Filed May 24, 2005, PCT No. PCT/JP2005/009465 § 371(c)(1), (2), (4) Date Jul. 11, 2007, PCT Pub. No. WO2006/126255, PCT Pub. Date Nov. 30, 2006.
Prior Publication US 2008/0139839 A1, Jun. 12, 2008
Int. Cl. C07C 269/04 (2006.01); C07C 269/08 (2006.01)

U.S. Cl. 560—161

11 Claims

1. A process for the production of tert-butyl N-(2-bromoethyl)carbamate, wherein 2-bromoethylamine or a salt thereof is made to react with an agent for introducing a tert-butoxy carbonyl group in a water-soluble solvent in the presence of sodium hydroxide and then water as a crystallizing solvent and seed crystals are added to the reaction solution whereby crystals of tert-butyl N-(2-bromoethyl)carbamate are separated out therefrom.