US 7,598,341 B2
	Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
Douglas Hanahan, San Francisco, Calif. (US); Erkki Ruoslahti, Rancho Santa Fe, Calif. (US); Johanna A. Joyce, New York, N.Y. (US); and Pirjo Laakkonen, Helsinki (Finland)
Assigned to Burnham Institue for Medical Research, La Jolla, Calif. (US); and The Regents of the Universtiy of California, Oakland, Calif. (US)
Filed on Oct. 29, 2004, as Appl. No. 10/977,367.
Claims priority of provisional application 60/516118, filed on Oct. 31, 2003.
Prior Publication US 2005/0245445 A1, Nov. 03, 2005
Int. Cl. C07K 5/00 (2006.01); C07K 14/00 (2006.01)

U.S. Cl. 530—300  [530/350; 530/329; 530/324]

45 Claims

1. An isolated peptide having a length of less than 60 amino acid residues and comprising the amino acid sequence selected from CRGRRST (SEQ ID NO:5), CRSRKG (SEQ ID NO:9), and CKAAKNK (SEQ ID NO:15), wherein said peptide selectively homes to premalignant pancreatic vasculature, malignant pancreatic vasculature or pancreatic tumor cells.