| US 7,598,303 B2 | ||
| Process for making an aqueous dispersion | ||
| Willie Lau, Lower Gwynedd, Pa. (US) | ||
| Assigned to Rohm and Haas Company, Philadelphia, Pa. (US) | ||
| Filed on Jan. 24, 2006, as Appl. No. 11/338,369. | ||
| Claims priority of provisional application 60/653783, filed on Feb. 17, 2005. | ||
| Prior Publication US 2006/0183839 A1, Aug. 17, 2006 | ||
| Int. Cl. A61K 8/73 (2006.01) | ||
| U.S. Cl. 524—27 [524/367; 524/457; 524/458; 524/460; 524/556; 524/801; 524/832; 524/853; 525/329.5; 525/329.7; 525/330.3; 525/333.3; 526/201] | 9 Claims |
| 1. A process for forming an aqueous dispersion having at least two polymeric components, comprising:
(i) forming at least one high molecular weight polymeric component; and,
(ii) forming at least one low molecular weight polymeric component according to formula I:
A-B (I) wherein A is derived from a chain transfer component that exhibits a water solubility at 25 to 50° C. of no greater than 150
millimoles/liter and B is a polymer chain; wherein the low molecular weight polymeric component is formed in the presence
of a macromolecular organic compound having a hydrophobic cavity selected from cyclodextrin, cyclodextrin derivatives, cyclic
oligosaccharides having a hydrophobic cavity, calyxarenes, cavitands and combinations thereof; wherein the low molecular weight
component is formed within the high molecular weight polymeric component; wherein the low molecular weight polymeric component
exhibits a number average molecular weight of no more than 10,000 and the high molecular weight polymeric component exhibits
a number average molecular weight of at least 50,000.
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