US 7,598,238 B2
Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof
Jeffrey D. Laskin, Piscataway, N.J. (US); Ned Heindel, Easton, Pa. (US); Diane Heck, Rumson, N.J. (US); Anna Marie Vetrano, North Brunswick, N.J. (US); Christophe Guillon, Bethlehem, Pa. (US); and Peter DeMatteo, Allentown, Pa. (US)
Assigned to University of Medicine and Dentistry of New Jersey, New Brunswick, N.J. (US); Rutgers, the State University, New Brunswick, N.J. (US); and Lehigh University, Bethlehem, Pa. (US)
Filed on Jul. 28, 2006, as Appl. No. 11/495,948.
Application 11/495948 is a continuation of application No. 10/922300, filed on Aug. 19, 2004, granted, now 7,105,511.
Prior Publication US 2006/0270664 A1, Nov. 30, 2006
Int. Cl. C07D 513/04 (2006.01); A61K 31/542 (2006.01)
U.S. Cl. 514—222.8  [544/10] 2 Claims
 
1. A method for inhibiting cancer cell proliferation comprising administering to cancer cells a compound of Formula II,

OG Complex Work Unit Drawing
wherein R is selected from the group consisting of a furyl, a thienyl, a pyridyl, an alkyl, an aryl or arylalkyl, a 1-(2-phenyl)-ethyl, a 3-methoxyphenyl, a 4-trifluoromethylphenyl and 4-fluorophenyl group, wherein said cancer cells are selected from the group consisting of squamous cell carcinoma, melanoma, colon cancer, cervical carcinoma and estrogen-dependent breast cancer.