| US 7,597,893 B2 | ||
| Human monoclonal antibody specific lipopolysaccharides (LPS) of serotype IATS 06 of Pseudomonas aeruginosa | ||
| Alois B. Lang, Helmberg (Switzerland); Michael P. Horn, Thun (Switzerland); and Martin A. Imboden, Münsingen (Switzerland) | ||
| Assigned to Kenta Biotech AG, (Switzerland) | ||
| Filed on Nov. 10, 2005, as Appl. No. 11/271,008. | ||
| Application 11/271008 is a continuation of application No. PCT/EP2004/004485, filed on Apr. 28, 2004. | ||
| Prior Publication US 2006/0093610 A1, May 04, 2006 | ||
| Int. Cl. A61K 39/40 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01) | ||
| U.S. Cl. 424—150.1 [424/130.1; 424/133.1; 424/137.1; 424/141.1; 424/142.1; 424/164.1; 424/170.1; 424/178.1; 530/809] | 21 Claims |
| 1. A human monoclonal antibody specific for LPS of the Pseudomonas aeruginosa LPS serotype IATS 06, wherein the variable region of the light chain of said antibody comprises the amino acid sequence of SEQ ID NO:7 and the variable region of the heavy chain of said antibody comprises the amino acid sequence of SEQ ID NO:8, or a variant of said antibody capable of binding said LPS, wherein the amino acid sequence of the variable region of the light chain of said variant of said antibody is at least 85% homologous to SEQ ID NO:7 and the amino acid sequence of the variable region of the heavy chain of said variant of said antibody is at least 85% homologous to SEQ ID NO:8. |