	US 7,595,398 B2
	N-(5-membered aromatic ring)-amido anti-viral compounds
Franz Ulrich Schmitz, Mill Valley, Calif. (US); Christopher Don Roberts, Belmont, Calif. (US); Ali Dehghani Mohammad Abadi, Campbell, Calif. (US); Ronald Conrad Griffith, Escondido, Calif. (US); Martin Robert Leivers, San Francisco, Calif. (US); Irina Slobodov, San Mateo, Calif. (US); and Roopa Rai, San Carlos, Calif. (US)
Assigned to SmithKline Beecham Corporation, Philadelphia, Pa. (US)
Filed on Dec. 12, 2006, as Appl. No. 11/609,858.
Claims priority of provisional application 60/749855, filed on Dec. 12, 2005.
Prior Publication US 2007/0265265 A1, Nov. 15, 2007
Int. Cl. C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61K 31/427 (2006.01)

U.S. Cl. 544—133 [548/148; 548/195; 514/371]

13 Claims

1. A compound having Formula (IIa) or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof,

wherein:

L²is —(CH₂)_nC(O)NH— or —(CH₂)_nNHC(O)—;

n is 0, 1, 2, 3, or 4;

R⁶is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic;

R⁷is selected from the group consisting of hydrogen, amino, substituted amino, halo, cyano, alkoxy, alkyl, substituted alkyl, nitro, substituted alkoxy, aryl, substituted aryl, substituted aryloxy, cycloalkyl, heterocyclic, substituted heterocyclic, hydroxyl, aminocarbonyl, substituted alkylthio, substituted sulfonyl, aminocarbonyl, aminocarbonylamino, and aminocarbonyloxy;

R⁵is selected from the group consisting of hydrogen, halo, alkyl, and substituted alkyl;

R¹is selected from the group consisting of amino, substituted amino, alkyl, arylalkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, aryloxy, arylalkoxy, —OR^1a, and —OCH₂R^1a; and

R^1ais selected from the group consisting of cycloalkyl, substituted cycloalkyl, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, and substituted heteroaryl.