US 7,595,389 B2
	siRNA targeting casitas B cell lymphoma-B (CBL-B)
Anastasia Khvorova, Boulder, Colo. (US); Angela Reynolds, Conifer, Colo. (US); Devin Leake, Denver, Colo. (US); William Marshall, Boulder, Colo. (US); Steven Read, Denver, Colo. (US); and Stephen Scaringe, Lafayette, Colo. (US)
Assigned to Dharmacon, Inc., Lafayette, Colo. (US)
Filed on Jul. 23, 2007, as Appl. No. 11/880,628.
Application 11/880628 is a continuation in part of application No. 10/940892, filed on Sep. 14, 2004.
Application 10/940892 is a continuation of application No. PCT/US2004/014885, filed on May 12, 2004.
Application 10/940892 is a continuation of application No. 11/880628.
Application 11/880628 is a continuation in part of application No. 10/714333, filed on Nov. 14, 2003.
Claims priority of provisional application 60/502050, filed on Sep. 10, 2003.
Claims priority of provisional application 60/426137, filed on Nov. 14, 2002.
Prior Publication US 2008/0293593 A1, Nov. 27, 2008
Int. Cl. C07H 21/04 (2006.01)

U.S. Cl. 536—24.5  [536/23.1]

20 Claims

1. An siRNA molecule, wherein said siRNA molecule consists of: (a) a duplex region; and (b) either no overhang regions or at least one overhang region that contains six or fewer nucleotides, wherein the duplex region consists of a sense region and an antisense region, wherein said sense region and said antisense region together form said duplex region and said duplex region is 19-30 base pairs in length and said antisense region comprises a sequence that is the complement of SEQ ID NO: 609 or SEQ ID NO: 535.