US 7,595,347 B2
	Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
Stephen C. Cosenza, Voorhees, N.J. (US); M. V. Ramana Reddy, Upper Darby, Pa. (US); and E. Premkumar Reddy, Villanova, Pa. (US)
Assigned to Temple University—Of The Commonwealth System of Higher Education, Philadelphia, Pa. (US)
Filed on May 21, 2004, as Appl. No. 10/851,829.
Application 10/851829 is a continuation of application No. 09/689281, filed on Oct. 11, 2000, granted, now 6,767,926.
Claims priority of provisional application 60/159123, filed on Oct. 12, 1999.
Prior Publication US 2004/0214903 A1, Oct. 28, 2004
Int. Cl. A61K 31/10 (2006.01); A61K 31/335 (2006.01); A61K 31/44 (2006.01); A61K 31/70 (2006.01); A61K 31/135 (2006.01); A61K 31/35 (2006.01)

U.S. Cl. 514—710  [514/709; 514/449; 514/283; 514/27; 514/656; 514/459]

18 Claims

1. A method for protecting an animal from cytotoxic side effects of the administration of a mitotic phase cell cycle inhibitor or a topoisomerase inhibitor comprising administering to the animal an effective amount of at least one cytoprotective α,β-unsaturated aryl sulfone compound, in advance of administration of said inhibitor, to reduce the toxicity of said inhibitor on normal cells of the animal, wherein the mitotic phase cell cycle inhibitor and topoisomerase inhibitor are other than an α,β-unsaturated aryl sulfone compound.