wherein the compound of Formula (I) is:

X₂ is —S(O)₂;

Y₂ is chlorine or CF₃;

—V₂—U₂—W₂— is:

(i) —NH—(C(R_q)(R_r))—NR_q—; or

(ii) —NH—C(R_q)═N—;

R_q and R_r at each occurrence are independently a hydrogen, a lower alkyl group, a substituted alkyl group, a benzyl group, an aryl group, an alkylaryl group, —CH₂—S—CH—CH═CH₂; —CH₂—S—CF₃, —CH₂—S—CH₂—C₆H₅ or K′ with the proviso that (R_q) and/or (R_r)with the carbon atom to which they are attached form a spiro ring;

K′ is -G-E_c-(C(R_e)(R_f))_x—W_d—(C(R_e)(R_f))_y—W_i-E_j-W_g—(C(R_e)(R_f))_z—V₄;

K is —(W)_a-E_b-(C(R_e)(R_f))_p1-E_c-(C(R_e)(R_f))_x—(W)_d—(C(R_e)(R_f))_y—(W)_i-E_j-(W)_g—(C(R_e)(R_f))_z—V₄;

a, b, c, d, g, i and j are each independently an integer from 0 to 3;

p₁, x, y and z are each independently an integer from 0 to 10;

G is a heterocyclic ring;

V₄ is V₃, R_e, —U₃—V₅ or V₆;

V₃ is:

R₂₄ is —C₆H₄R₂₉, —CN, —S(O)₂—C₆H₄R₂₉, —C(O)—N(R_a)(R_i), —NO₂, —C(O)—OR₂₅ or —S(O)₂—R₂₅;

R₂₅ is an aryl group, a lower alkyl group, a haloalkyl group, a hydroxyalkyl group or an arylalkyl group;

R₂₆ is —C(O)— or —S(O)₂—;

R₂₉ is a hydrogen, —CN, —S(O)₂—R₂₅, —C(O)—N(R_a)(R_i), —NO₂ or —C(O)—OR₂₅;

T′ is oxygen, sulfur or NR₆;

R₆ is a hydrogen, a lower alkyl group or an aryl group;

V₆ is:

Z₅ is —CH₂ or oxygen;

Z₆ is —CH or nitrogen;

k₁ is an integer from 1 to 3;

W at each occurrence is independently —C(O)—, —C(S)—, -T₃-, —(C(R_e)(R_f))_h—, —N(R_a)R_i, an alkyl group, an aryl group, a heterocyclic ring, an arylheterocyclic ring, —(CH₂CH₂O)_q1— or a heterocyclic nitric oxide donor;

E at each occurrence is independently -T₃-, an alkyl group, an aryl group, —(C(R_e)(R_f))_h—, a heterocyclic ring, an arylheterocyclic ring, —(CH₂CH₂O)_q1— or Y₄;

Y₄ is:

T is a —S(O)_o—; a carbonyl or a covalent bond;

o is an integer from 0 to 2;

R_j and R_k are independently selected from an alkyl group, an aryl group, or R_j and R_k taken together with the nitrogen atom to which they are attached are a heterocylic ring;

T₃ at each occurrence is independently a covalent bond, a carbonyl, an oxygen, —S(O)_o— or —N(R_a)R_i;

h is an integer form 1 to 10;

q₁ is an integer from 1 to 5;

R_e and R_f are each independently a hydrogen, an alkyl, a cycloalkoxy, a halogen, a hydroxy, an hydroxyalkyl, an alkoxyalkyl, an arylheterocyclic ring, an alkylaryl, an alkylcycloalkyl, an alkylheterocyclic ring, a cycloalkylalkyl, a cycloalkylthio, an arylalklythio, an arylalklythioalkyl, an alkylthioalkyl, a cycloalkenyl, an heterocyclicalkyl, an alkoxy, a haloalkoxy, an amino, an alkylamino, a dialkylamino, an arylamino, a diarylamino, an alkylarylamino, an alkoxyhaloalkyl, a sulfonic acid, a sulfonic ester, an alkylsulfonic acid, an arylsulfonic acid, an arylalkoxy, an alkylthio, an arylthio, a cyano, an aminoalkyl, an aminoaryl, an aryl, an arylalkyl, an alkylaryl, a carboxamido, an alkylcarboxamido, an arylcarboxamido, an amidyl, a carboxyl, a carbamoyl, an alkylcarboxylic acid, an arylcarboxylic acid, an alkylcarbonyl, an arylcarbonyl, an ester, a carboxylic ester, an alkylcarboxylic ester, an arylcarboxylic ester, a sulfonamido, an alkylsulfonamido, an arylsulfonamido, an alkylsulfonyl, an alkylsulfonyloxy, an arylsulfonyl, arylsulphonyloxy, a sulfonic ester, an alkyl ester, an aryl ester, a urea, a phosphoryl, a nitro, —U₃—V₅, V₆, —(C(R_o)(R_p))_k1—U₃—V₅, —(C(R_o)(R_p))_k1—U₃—V₃, —(C(R_o)(R_p))_k1—U₃—V₆, —(C(R_o)(R_p))_k1—U₃—C(O)—V₆, or R_e and R_f taken together with the carbons to which they are attached form a carbonyl, a methanthial, a heterocyclic ring, a cycloalkyl group, an aryl group, an oxime, an imine, a hydrazone, a bridged cycloalkyl group,

R_o and R_p are each independently a hydrogen, an alkyl, a cycloalkoxy, a halogen, a hydroxy, an hydroxyalkyl, an alkoxyalkyl, an arylheterocyclic ring, an alkylaryl, an alkylcycloalkyl, an alkylheterocyclic ring, a cycloalkylalkyl, a cycloalkylthio, an arylalklythio, an arylalklythioalkyl, an alkylthioalkyl a cycloalkenyl, an heterocyclicalkyl, an alkoxy, a haloalkoxy, an amino, an alkylamino, a dialkylamino, an arylamino, a diarylamino, an alkylarylamino, an alkoxyhaloalkyl, a sulfonic acid, a sulfonic ester, an alkylsulfonic acid, an arylsulfonic acid, an arylalkoxy, an alkylthio, an arylthio, a cyano an aminoalkyl, an aminoaryl, an aryl, an arylalkyl, an alkylaryl, a carboxamido, an alkylcarboxamido, an arylcarboxamido, an amidyl, a carboxyl, a carbamoyl, an alkylcarboxylic acid, an arylcarboxylic acid, an alkylcarbonyl, an arylcarbonyl, an ester, a carboxylic ester, an alkylcarboxylic ester, an arylcarboxylic ester, a sulfonamido, an alkylsulfonamido, an arylsulfonamido, an alkylsulfonyl, an alkylsulfonyloxy, an arylsulfonyl, arylsulphonyloxy, a sulfonic ester, an alkyl ester, an aryl ester, a urea, a phosphoryl, a nitro, —U₃—V₅, V₆, or R_o and R_p taken together with the carbons to which they are attached form a carbonyl, a methanthial, a heterocyclic ring, a cycloalkyl group, an aryl group, an oxime, an imine, a hydrazone a bridged cycloalkyl group,

U₃ is an oxygen, sulfur or —N(R_a)R_i;

V₅ is —NO or —NO₂ (i.e. an oxidized nitrogen);

k₁ is an integer from 1 to 3;

R_a is a lone pair of electrons, a hydrogen or an alkyl group;

R_i is a hydrogen, an alkyl, an aryl, an alkylcarboxylic acid, an arylcarboxylic acid, an alkylcarboxylic ester, an arylcarboxylic ester, an alkylcarboxamido, an arylcarboxamido, an alkylaryl, an alkylsulfinyl, an alkylsulfonyl, an alkylsulfonyloxy, an arylsulfinyl, an arylsulfonyl, an arylsulphonyloxy, a sulfonamido, a carboxamido, a carboxylic ester, an aminoalkyl, an aminoaryl, —CH₂—C—(U₃—V₅)(R_e)(R_f), a bond to an adjacent atom creating a double bond to that atom or —(N₂O₂—).M₁⁺, wherein M₁⁺ is an organic or inorganic cation; and

with the proviso that the compound of Formula (I) must contain at least one group selected from a —ONO group, a —SNO group, a —NNO group, a —ONO₂ group, -a SNO₂ group, a —NNO₂ group, a —(N₂O₂—).M₁⁺ group, a heterocyclic nitric oxide donor group and a nitroxide group where the group is linked to the compound of Formula (I) through a carbon, oxygen or nitrogen atom via a bond that cannot be hydrolyzed.