US 7,595,305 B2
Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
Sudhir Agrawal, Shrewsbury, Mass. (US); Lakshmi Bhagat, Framingham, Mass. (US); Dong Yu, Westboro, Mass. (US); and Ekambar Kandimalla, Southboro, Mass. (US)
Assigned to Idera Pharmaceuticals, Cambridge, Mass. (US)
Filed on Jul. 01, 2005, as Appl. No. 11/173,794.
Application 11/173794 is a continuation of application No. 10/757345, filed on Jan. 14, 2004.
Claims priority of provisional application 60/440587, filed on Jan. 16, 2003.
Prior Publication US 2006/0287261 A1, Dec. 21, 2006
Int. Cl. C07H 21/02 (2006.01); C07H 21/04 (2006.01); A01N 43/04 (2006.01); A61K 31/70 (2006.01)
U.S. Cl. 514—44  [514/45; 536/23.1] 7 Claims
 
1. An immunostimulatory oligonucleotide having the structure 5′-TCG1TCG1TTCTG-X-GTCTTG1CTG1CT-5′; wherein X is a glycerol linker and G1 is 2′-deoxy-7-deazaguanosine.