US 7,595,023 B2
Spatiotemporal and geometric optimization of sensor arrays for detecting analytes in fluids
Nathan S. Lewis, La Canada, Calif. (US); Michael S. Freund, Winnipeg (Canada); Shawn S. Briglin, Chittenango, N.Y. (US); Phillip Tokumaru, Moorpark, Calif. (US); Charles R. Martin, Gainesville, Fla. (US); and David Mitchell, Newtown, Pa. (US)
Assigned to The California Institute of Technology, Pasadena, Calif. (US); University of Florida, Gainesville, Fla. (US); and Aerovironment, Inc., Monrovia, Calif. (US)
Filed on Jul. 20, 2006, as Appl. No. 11/490,732.
Application 11/490732 is a division of application No. 09/842204, filed on Apr. 24, 2001, granted, now 7,122,152.
Application 09/842204 is a continuation in part of application No. 09/568784, filed on May 10, 2000, granted, now 6,455,319.
Claims priority of provisional application 60/133318, filed on May 10, 1999.
Claims priority of provisional application 60/140027, filed on Jun. 16, 1999.
Claims priority of provisional application 60/199221, filed on Apr. 24, 2000.
Claims priority of provisional application 60/235385, filed on Sep. 25, 2000.
Prior Publication US 2009/0214762 A1, Aug. 27, 2009
Int. Cl. C12Q 1/68 (2006.01)
U.S. Cl. 422—62  [422/68.1; 422/88; 436/55] 19 Claims
OG exemplary drawing
 
1. A method of fabricating a sensor array for detecting an analyte in a fluid, comprising:
providing a substrate having a surface and a sampling headspace proximate to the surface and separated from the environment;
exposing at least one sensing material to at least one target analyte;
identifying a sampling headspace volume Vl for at least a portion of the sampling headspace, and a partition coefficient K of at least one target analyte in the sensing material;
calculating a sensor volume, Vp, based on the sampling headspace volume and the partition coefficient;
and fabricating a sensor by placing the at least one sensing material on the surface proximate to the at least a portion of the sampling headspace, the sensor including an amount of the sensing material derived from the calculated sensor volume.