| US 7,592,336 B2 | ||
| Hepatitis C virus inhibitors | ||
| Ny Sin, East Hampton, Conn. (US); Paul Michael Scola, Glastonbury, Conn. (US); Nicholas A. Meanwell, East Hampton, Conn. (US); Xiangdong Alan Wang, Guilford, Conn. (US); Li-Qiang Sun, Glastonbury, Conn. (US); Jie Chen, Madison, Conn. (US); and Andrew Charles Good, Wallingford, Conn. (US) | ||
| Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US) | ||
| Filed on May 09, 2006, as Appl. No. 11/430,611. | ||
| Claims priority of provisional application 60/679628, filed on May 10, 2005. | ||
| Prior Publication US 2008/0152619 A1, Jun. 26, 2008 | ||
| Int. Cl. A61K 31/5377 (2006.01); A61K 31/454 (2006.01); A61K 31/4025 (2006.01); A61K 31/40 (2006.01); C07D 413/10 (2006.01); C07D 401/10 (2006.01); C07D 207/04 (2006.01) | ||
| U.S. Cl. 514—235.5 [514/326; 514/422; 514/423; 544/141; 546/208; 548/518; 548/537] | 18 Claims |
1. A compound of formula (I)
 n is 1, 2, or 3;
R1 is selected from and —NHSO2R7;
R2 is selected from hydrogen, alkenyl, alkyl, cyanoalkyl, cycloalkyl, and haloalkyl;
R3 is selected from alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and heterocyclylalkyl;
R4 is selected from hydrogen and hydroxy;
R5 is selected from alkenyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, arylalkyl, carboxyalkyl, cyanoalkyl, cycloalkyl, (cycloalkyl)alkyl,
haloalkyl, hydroxyalkyl, and (NRaRb)alkyl;
R6 is selected from alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, aryl, cycloalkyl, heterocyclyl, (NRaRb)carbonyl, and (NRaRb)sulfonyl;
R7 is selected from alkyl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and —NRcRd;
Ra and Rb are independently selected from alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, and heterocyclylalkyl; and
Rc and Rd are independently selected from alkoxy, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and heterocyclylalkyl;
or Rc and Rd together with the nitrogen atom to which they are attached form a five or six-membered monocyclic heterocyclic ring;
provided that when R4 is hydrogen, R3 is other than heterocyclyl.
|