	US 7,592,335 B2
	Oxazolidinone derivatives as antimicrobials
Biswajit Das, Haryana (India); Sonali Rudra, Haryana (India); Sangita Sangita, Allahabad (India); Mohammad Salman, Princeton, N.J. (US); and Ashok Rattan, Haryana (India)
Assigned to Ranbaxy Laboratories Limited, Gurgaon (India)
Appl. No. 11/911,576 PCT Filed Apr. 12, 2006, PCT No. PCT/IB2006/000871 § 371(c)(1), (2), (4) Date Apr. 10, 2008, PCT Pub. No. WO2006/109156, PCT Pub. Date Oct. 19, 2006.
Claims priority of application No. 951/05 (IN), filed on Apr. 15, 2005.
Prior Publication US 2008/0188470 A1, Aug. 07, 2008
Int. Cl. C07D 498/04 (2006.01); A61K 31/5383 (2006.01)

U.S. Cl. 514—230.5 [544/105]

8 Claims

1. A compound of Formula I,

and their pharmaceutically acceptable salts, pharmaceutically acceptable esters, enantiomers, diastereomers, or N-oxides, wherein U and V are selected from hydrogen and fluorine (wherein both U and V cannot simultaneously be hydrogen);

A is selected from;

R is H, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl, —COR_a, —C(O)OR_a, or S(O)₂R_a;

R₁is azido, halogen, NCS, NHYR_fNR_jC(=T)NR_fR_q, NR_fR_qor NR_j(C═O)OR_s( );

R_ais selected from hydrogen, straight or branched unsubstituted or substituted alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl;

Y is (C═O), (C═S) or SO₂;

R_fis hydrogen, alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl;

T is O, S, —N(CN), —N(NO₂), or —CH(NO₂);

R_jis hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, heteroarylalkyl or heterocyclylalkyl;

R_qis hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, heteroarylalkyl or heterocyclylalkyl, and

R_sis alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heteroarylalkyl or heterocyclylalkyl.