US 11,756,661 B2
Apparatus for optimizing a patient's insulin dosage regimen
Eran Bashan, Ann Arbor, MI (US); and Israel Hodish, Ann Arbor, MI (US)
Assigned to HYGIEIA, INC., Ann Arbor, MI (US)
Filed by Hygieia, Inc., Livonia, MI (US)
Filed on May 20, 2019, as Appl. No. 16/417,102.
Application 16/417,102 is a continuation of application No. 14/067,479, filed on Oct. 30, 2013, granted, now 10,335,546.
Application 14/067,479 is a continuation of application No. 12/417,955, filed on Apr. 3, 2009, granted, now 8,600,682, issued on Dec. 3, 2013.
Claims priority of provisional application 61/060,645, filed on Jun. 11, 2008.
Claims priority of provisional application 61/042,487, filed on Apr. 4, 2008.
Prior Publication US 2019/0365996 A1, Dec. 5, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. G16H 20/17 (2018.01); A61B 5/145 (2006.01); G16H 10/00 (2018.01); A61M 5/172 (2006.01); G16H 20/10 (2018.01); A61B 5/00 (2006.01); A61M 5/142 (2006.01)
CPC G16H 20/17 (2018.01) [A61B 5/14532 (2013.01); A61M 5/1723 (2013.01); G16H 10/00 (2018.01); G16H 20/10 (2018.01); A61B 5/0002 (2013.01); A61M 5/142 (2013.01)] 23 Claims
OG exemplary drawing
 
1. An apparatus for improving a patient's insulin dosage regimen, comprising:
at least one computer-readable memory for storing: programming instructions, data inputs corresponding at least to one or more components in the patient's insulin dosage regimen, and a patient's blood-glucose-level measurements determined at a plurality of times within a predefined period of time;
a timer for monitoring the predefined period of time, the timer being incremented based on at least one of: passage of a separate predetermined increment of time or receipt of at least one of the patient's blood-glucose-level measurements;
a display operative to display information corresponding to at least the patient's insulin dosage regimen; and
a processor configured to communicate with the at least one computer-readable memory and to execute the programming instructions stored in the at least one computer-readable memory to cause the apparatus to perform a method comprising:
(i) determining a number that represents excessive hypoglycemic events within the predefined period of time;
(ii) determining, after obtaining at least one blood-glucose-level measurement but before obtaining a subsequent blood]-glucose-level measurement, whether the obtained blood-glucose-level measurement reflects a hypoglycemic event or a severe hypoglycemic event;
(iii) reducing at least one of the one or more components in the patient's insulin dosage regimen in response to a determination that the obtained blood-glucose-level measurement represents a severe hypoglycemic event;
(iv) reducing at least one of the one or more components in the patient's insulin dosage regimen in response to a determination that the obtained blood-glucose-level measurements results in an excessive number of hypoglycemic events during the predefined period of time; wherein the timer is reinitiated after the determination that there have been an excessive number of hypoglycemic events over the predefined period of time;
(v) determining, at the end of the predefined period of time, from a plurality of the data corresponding to the patient's blood-glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient's insulin dosage regimen in order to maintain the patient's blood-glucose-level measurements within a predefined range; and
(vi) communicating the revised at least one of the one or more components in the patient's insulin dosage regimen to the display to enable the patient's insulin dosage regimen to be updated on the display;
wherein the timer is reinitiated after the determination of whether and by how much to vary at least one of the one or more components in the patient's insulin dosage regimen; and
wherein the processor is connected to a network that is accessible to a healthcare provider and through which data are input and information related to the patient's insulin dosage regimen are communicated.