CPC G01N 35/00693 (2013.01) [C12Q 1/6851 (2013.01); G16B 40/00 (2019.02); G01N 2035/00653 (2013.01); G01N 2035/00702 (2013.01); G01N 2035/00881 (2013.01)] | 39 Claims |
1. A system for determining a dose of an analyte in an unknown sample using a reagent from a selected assay lot, the system comprising:
a measurement device to measure response information of the analyte using a reagent from the assay lot; and
a processor in communication with the measurement device, the processor configured to:
receive a core dose-response curve defined by a model including at least one parameter estimate, wherein each parameter estimate is associated with at least one probability density, and wherein each probability density is a combination of a lot-specific density contribution and an instrument-specific density contribution;
receive information based on measurements of response values of one or more calibrator adjusters on the instrument using the assay lot;
receive a measured response of the unknown sample made on the instrument using the assay lot; and
determine the dose of the analyte in the unknown sample using an instrument-specific, selected lot-specific dose-response curve and the measured response of the unknown sample, wherein the instrument-specific, selected lot-specific dose-response curve is generated using the model, the transmitted plurality of parameter estimates, the transmitted plurality of probability densities, and the response values of the one or more calibration adjusters.
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