US 11,754,575 B2
Core calibration of analyzers
Mark Holland, Little Canada, MN (US); and Conan Dewitt, Eagan, MN (US)
Assigned to BECKMAN COULTER, INC., Brea, CA (US)
Appl. No. 16/314,261
Filed by Beckman Coulter, Inc., Brea, CA (US)
PCT Filed Jun. 30, 2017, PCT No. PCT/US2017/040244
§ 371(c)(1), (2) Date Dec. 28, 2018,
PCT Pub. No. WO2018/005945, PCT Pub. Date Jan. 4, 2018.
Claims priority of provisional application 62/357,090, filed on Jun. 30, 2016.
Prior Publication US 2019/0162739 A1, May 30, 2019
Int. Cl. G01N 35/00 (2006.01); G16B 40/00 (2019.01); C12Q 1/6851 (2018.01)
CPC G01N 35/00693 (2013.01) [C12Q 1/6851 (2013.01); G16B 40/00 (2019.02); G01N 2035/00653 (2013.01); G01N 2035/00702 (2013.01); G01N 2035/00881 (2013.01)] 39 Claims
 
1. A system for determining a dose of an analyte in an unknown sample using a reagent from a selected assay lot, the system comprising:
a measurement device to measure response information of the analyte using a reagent from the assay lot; and
a processor in communication with the measurement device, the processor configured to:
receive a core dose-response curve defined by a model including at least one parameter estimate, wherein each parameter estimate is associated with at least one probability density, and wherein each probability density is a combination of a lot-specific density contribution and an instrument-specific density contribution;
receive information based on measurements of response values of one or more calibrator adjusters on the instrument using the assay lot;
receive a measured response of the unknown sample made on the instrument using the assay lot; and
determine the dose of the analyte in the unknown sample using an instrument-specific, selected lot-specific dose-response curve and the measured response of the unknown sample, wherein the instrument-specific, selected lot-specific dose-response curve is generated using the model, the transmitted plurality of parameter estimates, the transmitted plurality of probability densities, and the response values of the one or more calibration adjusters.