US 11,754,504 B2
System for analog light measuring and photon counting in chemiluminescence measurements
Brian Kozicki, Saint Louis Park, MN (US); Creigh Thompson, Chaska, MN (US); Richard Wolf, Savage, MN (US); Laura Holmes, Minnetonka, MN (US); and David Sorrentino, Chaska, MN (US)
Assigned to Beckman Coulter, Inc., Brea, CA (US)
Appl. No. 16/648,609
Filed by Beckman Coulter, Inc., Brea, CA (US)
PCT Filed Sep. 19, 2018, PCT No. PCT/US2018/051682
§ 371(c)(1), (2) Date Mar. 18, 2020,
PCT Pub. No. WO2019/060375, PCT Pub. Date Mar. 28, 2019.
Claims priority of provisional application 62/560,636, filed on Sep. 19, 2017.
Claims priority of provisional application 62/560,638, filed on Sep. 19, 2017.
Prior Publication US 2020/0217800 A1, Jul. 9, 2020
Int. Cl. G01N 21/76 (2006.01); G01N 21/27 (2006.01); G01J 1/44 (2006.01)
CPC G01N 21/76 (2013.01) [G01J 1/44 (2013.01); G01N 21/27 (2013.01); G01N 21/272 (2013.01); G01J 2001/444 (2013.01); G01N 2201/022 (2013.01); G01N 2201/12753 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A system for performing an assay, the system comprising:
a chassis, comprising:
a reaction vessel chamber, and
a light passage comprising a first end and a second end, the light passage intersecting the reaction vessel chamber;
a cap that, when in a closed configuration, forms a dark chamber by preventing light emitted by external light sources from entering the reaction vessel chamber and from entering the light passage, and, when in an open configuration, provides access to the reaction vessel chamber;
a calibration light source optically coupled to the first end of the light passage;
a light detector optically coupled to the second end of the light passage, the light detector comprising:
a sensing element for receiving light from the light passage;
a thermal cavity within the chassis, the light detector at least partially positioned within the thermal cavity;
a thermal cover positioned over an opening of the thermal cavity; and
a thermally conductive gasket that thermally couples the thermal cover to the chassis;
wherein the thermal cavity and the thermal cover define an enclosed volume; and
wherein the light detector is positioned within the enclosed volume.