CPC C07D 401/14 (2013.01) | 19 Claims |
1. A compound selected from the following Formulas:
or a pharmaceutically acceptable salt thereof;
wherein:
R1 is selected from:
a. haloalkyl and alkyl; either of which is optionally substituted with 1, 2, or 3 substituents independently selected from aryl, cycloalkyl, heteroaryl, —SO2R5, —NR2—C(O)—R3, —C(O)OR4, and —C(O)—R3; wherein when the haloalkyl or alkyl group has two or more carbons it can additionally be optionally substituted with 1, 2, 3, or 4 substituents independently selected from —OC(O)—R3, —NR4R4, and —OR4, wherein these additional substituents are not on the carbon alpha to the pyrazole;
b. cycloalkyl and aryl; either of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, and —C(O)—R3;
c. heteroaryl optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, —NR4R4, —OR4, —NR2—C(O)—R3, —O—C(O)—R3, and —C(O)—R3; wherein the heteroaryl group is only substituted such that no N—O or N—N bonds are formed;
d. heterocycle substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, —SO2R5, —C(O)—R5, and R5; wherein the heterocycle group is only substituted such that no N—O or N—N bonds are formed;
e. (CR4R2)—(CR2R2)o-heterocycle optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, —SO2R5, —C(O)—R5, and R5; wherein the heterocycle group is only substituted such that no N—O or N—N bonds are formed; and
f. bicyclic heterocycle or multicyclic heterocycle optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, —SO2R5, —C(O)—R5, and R5; wherein the bicyclic heterocycle group is only substituted such that no N—O or N—N bonds are formed;
R2 at each instance is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocycle, heteroaryl, and cycloalkyl;
R3 is selected from hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, aryl, heterocycle, heteroaryl, —NR2R2, and —OR4;
R4 at each instance is independently selected from hydrogen, alkyl, alkenyl, cycloalkyl, haloalkyl, aryl, heterocycle, heteroaryl, and alkynyl;
R5 is selected from hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heteroaryl, heterocycle, aryl, —O-cycloalkyl, —O-aryl, —O-heteroaryl, —O-heterocycle, —O-alkyl, —NR2— cycloalkyl, —NR2-aryl, —NR2-heteroaryl, —NR2-heterocycle, —NR2-alkyl, —CH2-cycloalkyl, —CH2-aryl, —CH2-heteroaryl, —CH2-heterocycle, —OR2, and —NR2R2; each of which except for hydrogen is optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocycle, aryl, heteroaryl, cyano, halogen, —OR2, and —NR2R2;
m and o are independently selected from 0, 1, 2, 3, 4, and 5;
x is 0, 1, 2, 3, or 4;
n is 0, 1, 2, 3, or 4;
y is 1, 2, 3, 4, 5, or 6;
R11 is selected from
a. haloalkyl and alkyl; each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from —NR2—C(O)—R3, —O—C(O)—R3, and —C(O)—R3; wherein when the haloalkyl or alkyl group has two or more carbons it can additionally be optionally substituted with 1, 2, 3, or 4 substituents independently selected from —OC(O)—R3, —NR4R4, and —OR4, wherein these additional substituents are not on the carbon alpha to the pyrazole;
b. cycloalkyl, heteroaryl, and aryl; each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, F, Cl, Br, I, cyano, heteroaryl, aryl, cycloalkyl, —NR4R4, —OR4, —NR2—C(O)—R3, —O—C(O)—R3, and —C(O)—R3;
c. (CR2R2)n-heterocycle substituted with 1, 2, 3, or 4 substituents independently selected from alky, alkenyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, —NR4R4, —OR4, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, and —SO2R5; wherein the heterocycle group is only substituted such that no N—O or N—N bonds are formed; and
d. bicyclic heterocycle optionally substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, —SO2R5, —C(O)—R5, and R5; wherein the bicyclic heterocycle group is only substituted such that no N—O or N—N bonds are formed;
R12 is selected from alkyl, haloalkyl, alkenyl, alkynyl, heteroaryl, aryl, cycloalkyl, heterocycle, —C(O)—R3, —SO2R5, and —C(O)—R5;
R13 at each instance is independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R3, —O—C(O)—R3, —C(O)—R3, —SO2R5, —C(O)—R5, and R5; or two R13s may together with the carbon(s) to which they are attached be replaced with a spiro or fused, heterocycle or carbocycle ring, or two R13s may together with the carbon to which they are attached be replaced with an aryl ring;
R20 is heterocycle substituted with 1, 2, 3, or 4 substituents independently selected from alkyl, alkenyl, alkynyl, halogen, cyano, heteroaryl, aryl, cycloalkyl, heterocycle, —NR2R2, —OR2, —NR2—C(O)—R24, —O—C(O)—R24, —C(O)—R24, —SO2R24, and R24; wherein the heterocycle group is only substituted such that no N—O or N—N bonds are formed;
R21 and R22 are independently selected from hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, —(C2-C6alkenylene)-cycloalkyl, —(C2-C6alkynylene)-cycloalkyl, halogen, and cyano;
R23a and R23b are independently selected from hydrogen, alkyl, cycloalkyl, and —(C1-C6alkylene)-NR2R2;
or R21 and R23a are joined together with the carbons to which they are attached to form a 5- to 6-membered carbocyclic ring;
or R22 and R23a are joined together with the carbons to which they are attached to form a 5- to 6-membered carbocyclic ring;
R24 is selected at each occurrence from alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heteroaryl, heterocycle, aryl, —O-cycloalkyl, —O-aryl, —O-heteroaryl, —O-heterocycle, —O-alkyl, —NR2-cycloalkyl, —NR2-aryl, —NR2-heteroaryl, —NR2-heterocycle, —NR2-alkyl, —CH2-cycloalkyl, —CH2-aryl, —CH2-heteroaryl, —CH2-heterocycle, —OR2, and —NR2R2; wherein each R24 is optionally substituted with 1, 2, 3, or 4 groups independently selected from R25; and
R25 is selected at each occurrence from: alkyl; alkenyl; alkynyl; haloalkyl; cycloalkyl; heterocycle; aryl optionally substituted with 1, 2, or 4 groups independently selected from alkyl, alkoxy, or halogen; heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from alkyl, alkoxy, or halogen; —CH2-cycloalkyl; —CH2-aryl optionally substituted with 1, 2, or 3 groups independently selected from alkyl, alkoxy, or halogen; —CH2-heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from alkyl, alkoxy, or halogen; —CH2-heterocycle; —CH2—NH—C(O)CH3; —C(O)-cycloalkyl; —C(O)-aryl optionally substituted with 1, 2, or 3 groups independently selected from alkyl, alkoxy, or halogen; —C(O)-heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from alkyl, alkoxy, or halogen; —C(O)-heterocycle; —C(O)-alkyl; —(C2-C6alkenylene)-aryl; —(C2-C6alkynylene)-aryl; —(C2-C6alkenylene)-cycloalkyl; —(C2-C6alkynylene)-cycloalkyl; —C(O)—(C1-C6alkylene)-O-alkyl; —C(O)—(C1-C6alkylene)-aryl; cyano; halogen; —OR2; and —NR2R2; or
two R25 groups may join together with the atoms to which they are attached to form a 3- to 7-membered carbocyclic ring.
|