US 11,753,366 B2
Tetrahydro-1H-cyclopenta[cd]indene derivatives as hypoxia inducible factor-2(alpha) inhibitors
Jiping Fu, Danville, CA (US); Yan Lou, Dallas, TX (US); and Yigang He, Newark, DE (US)
Assigned to NIKANG THERAPEUTICS, INC., Wilmington, DE (US)
Filed by NIKANG THERAPEUTICS, INC., Wilmington, DE (US)
Filed on Feb. 11, 2022, as Appl. No. 17/670,423.
Application 17/670,423 is a continuation of application No. 17/218,129, filed on Mar. 30, 2021, granted, now 11,267,782.
Application 17/218,129 is a continuation of application No. 16/851,018, filed on Apr. 16, 2020, abandoned.
Claims priority of provisional application 62/946,191, filed on Dec. 10, 2019.
Claims priority of provisional application 62/836,019, filed on Apr. 18, 2019.
Prior Publication US 2022/0162158 A1, May 26, 2022
Int. Cl. C07D 213/63 (2006.01); C07D 213/65 (2006.01); C07C 255/54 (2006.01); C07C 255/50 (2006.01); C07C 313/06 (2006.01); A61P 35/00 (2006.01); A61P 1/16 (2006.01); A61P 9/12 (2006.01); A61P 29/00 (2006.01); A61K 45/06 (2006.01); A61K 31/277 (2006.01); A61K 31/4412 (2006.01); C07D 233/60 (2006.01)
CPC C07C 255/54 (2013.01) [A61P 35/00 (2018.01); C07C 313/06 (2013.01); C07D 213/63 (2013.01); C07D 233/60 (2013.01); A61K 45/06 (2013.01); C07C 2603/10 (2017.05); C07C 2603/97 (2017.05)] 6 Claims
 
1. A compound of Formula:

OG Complex Work Unit Chemistry
wherein:
R2 and R9 together with the carbon atom to which they are attached form

OG Complex Work Unit Chemistry
 or oxo; or
R2 is hydrogen and R9 is hydroxy.