CPC A61K 47/6883 (2017.08) [A61K 47/60 (2017.08); A61P 3/10 (2018.01); C07K 14/62 (2013.01); A61K 38/00 (2013.01)] | 19 Claims |
1. A conjugate of Formula 1:
X-La-F [Formula 1]
wherein in Formula 1,
X is an insulin analog consisting of an A-chain of SEQ ID NO: 55 of Formula 2 and a B-chain of SEQ ID NO: 56 of Formula 3 with the proviso that the peptide where the A-chain coincides with SEQ ID NO: 53 while the B-chain also coincides with SEQ ID NO: 54 is excluded;
L is a linker;
a is 0 or a natural number, with the proviso that when a is 2 or greater, each L is independent from each other;
F is a substance capable of increasing the half-life of X; and
X, L, and F are linked to each other by a covalent bond in the order of Formula 1:
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wherein:
in Formula 2, Xaa1 is glycine, Xaa5 is glutamine, Xaa12 is serine, Xaa14 is aspartic acid, Xaa16 is leucine, Xaa19 is tyrosine, and Xaa21 is asparagine; and
in Formula 3, Xaa16 is tyrosine, Xaa25 is phenylalanine, Xaa27 is threonine, and Xaa28 is proline.
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