US 11,752,210 B2
Sensitizing composition using electromagnetic waves for thermal therapy of cancers, and cancer therapy using same
Hyeon Jin Kim, Jeollabuk-do (KR); Seong Tshool Hong, Jeonju-si (KR); Hea Jong Chung, Jeonju-si (KR); Heui Kwan Lee, Jeonju-si (KR); Hea Guk Cho, Gwangju (KR); and Jae Gak Yu, Chungcheongnam-do (KR)
Assigned to JINIS CO., LTD., Wanju-gun (KR)
Filed by JINIS CO., LTD., Jeollabuk-do (KR)
Filed on Nov. 4, 2022, as Appl. No. 17/981,080.
Application 17/981,080 is a division of application No. 17/219,479, filed on Mar. 31, 2021, abandoned.
Application 17/219,479 is a continuation of application No. 15/029,726, abandoned, previously published as PCT/KR2014/009641, filed on Oct. 14, 2014.
Claims priority of application No. 10-2013-0123051 (KR), filed on Oct. 16, 2013; and application No. 10-2014-0109008 (KR), filed on Aug. 21, 2014.
Prior Publication US 2023/0079782 A1, Mar. 16, 2023
Int. Cl. A61K 41/00 (2020.01); A61K 38/40 (2006.01); A61K 33/06 (2006.01); A61K 33/24 (2019.01); A61K 33/26 (2006.01); A61K 45/06 (2006.01); A61N 5/02 (2006.01); A61N 5/06 (2006.01); A61N 5/10 (2006.01)
CPC A61K 41/0052 (2013.01) [A61K 33/06 (2013.01); A61K 33/24 (2013.01); A61K 33/26 (2013.01); A61K 38/40 (2013.01); A61K 45/06 (2013.01); A61N 5/02 (2013.01); A61N 5/062 (2013.01); A61N 2005/0659 (2013.01); A61N 2005/0661 (2013.01); A61N 2005/0662 (2013.01); A61N 2005/1098 (2013.01)] 4 Claims
 
1. A method of treating an animal subject with cancer, consisting of:
(a) administering a composition to the animal subject,
wherein the composition consists of
(i) a sensitizer which is a metal ion-carbohydrate complex in which (i-a) a metal ion selected from the group consisting of an iron ion and a magnesium ion is noncovalently bound to (i-b) a carbohydrate selected from the group consisting of carboxymaltose, isomaltoside, and starch; and
(ii) water as a pharmaceutically acceptable carrier, and
wherein the administering the composition results in localization of the metal ion of the metal-carbonhydrate complex in a cancerous tissue of the animal; and
(b) applying electromagnetic waves to the animal subject thereby generating amplified heat at cancerous tissue compared to non-cancerous tissues,
wherein the applying electromagnetic waves causes a decrease in a size of cancerous mass of the cancerous tissue.