	US 11,752,177 B2
	Method of reducing tobacco addiction in smoking subject with lactobacillus fermentum GKF3
Chin-Chu Chen, Taiwan (CN); Yen-Lien Chen, Taiwan (CN); Shih-Wei Lin, Taiwan (CN); Yen-Po Chen, Taiwan (CN); Ci-Sian Wang, Taiwan (CN); Yu-Hsin Hou, Taiwan (CN); Yang-Tzu Shih, Taiwan (CN); Ching-Wen Lin, Taiwan (CN); Ya-Jyun Chen, Taiwan (CN); Jia-Lin Jiang, Taiwan (CN); You-Shan Tsai, Taiwan (CN); and Zi-He Wu, Taiwan (CN)
Assigned to GRAPE KING BIO LTD, Taiwan (CN)
Filed by GRAPE KING BIO LTD, Taiwan (CN)
Filed on Dec. 17, 2021, as Appl. No. 17/554,626.
Claims priority of application No. TW110139393 (TW), filed on Oct. 22, 2021.
Prior Publication US 2023/0128854 A1, Apr. 27, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61P 25/34 (2006.01); C12N 1/20 (2006.01); A61K 9/00 (2006.01); C12R 1/225 (2006.01); A61K 35/742 (2015.01)

CPC A61K 35/742 (2013.01) [A61K 9/0053 (2013.01); A61P 25/34 (2018.01); C12N 1/205 (2021.05); C12R 2001/225 (2021.05)]

12 Claims

1. A method of reducing tobacco addiction in a smoking subject comprising daily administering to the smoking subject an oral composition consisting of an effective dosage of Lactobacillus fermentum GKF3 as an active ingredient, wherein the Lactobacillus fermentum GKF3 is deposited in China General Microbiological Culture Collection Center (CGMCC) with an accession number CGMCC 15203 on Jan. 12, 2018, the smoking subject excludes one taking a nicotine related replacement therapy, and a total amount of nicotine metabolites is reduced by 10 ng/mL to 1,100 ng/mL in urine of the smoking subject daily administered with the oral composition when compared to a corresponding smoking subject not administered with the oral composition.