CPC A61K 31/135 (2013.01) [A61K 9/7084 (2013.01); A61K 9/7053 (2013.01); A61P 25/24 (2018.01)] | 8 Claims |
1. A transdermal therapeutic system comprising a backing layer which is not permeable for the active ingredient, and at least one matrix layer on one side of the backing layer, wherein the matrix layer includes at least one pressure sensitive adhesive comprising an acrylic copolymer including free hydroxyl groups and no free carboxyl groups, and (S)-ketamine or a pharmaceutically acceptable salt or solvate thereof, and a penetration enhancer comprising a mixture of levulinic acid and methyl laurate, wherein the matrix layer has an area weight of 100 to 275 g/m2, wherein the methyl laurate is present in an amount greater than the levulinic acid, and wherein the weight ratio of levulinic acid to methyl laurate is between about 1:1.66 and 1:1.68.
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