US 11,752,109 B2
Controlling water release from a dimensionally stable aqueous composition
Florian Hammes, Andernach (DE); and René Eifler, Koblenz (DE)
Assigned to LTS Lohmann Therapie-Systeme AG, Andernach (DE)
Appl. No. 16/71,156
Filed by LTS Lohmann Therapie-Systeme AG, Andernach (DE)
PCT Filed Jul. 17, 2017, PCT No. PCT/EP2017/050866
§ 371(c)(1), (2) Date Jul. 19, 2018,
PCT Pub. No. WO2017/125376, PCT Pub. Date Jul. 27, 2017.
Claims priority of application No. 16152059 (EP), filed on Jan. 20, 2016.
Prior Publication US 2019/0365662 A1, Dec. 5, 2019
Int. Cl. A61K 9/70 (2006.01); A61K 9/00 (2006.01); A61K 31/485 (2006.01); A61P 25/04 (2006.01)
CPC A61K 9/7061 (2013.01) [A61K 9/0014 (2013.01); A61K 31/485 (2013.01)] 15 Claims
 
1. A system consisting of a closed, liquid-tight packaging, with an optional at least one mechanical means for opening, perforating or destroying the packaging;
wherein a hydrous composition is enclosed in said liquid-tight packaging, said hydrous composition comprising a sufficient amount of an activating agent, and
wherein a liquid phase is also enclosed within said closed liquid-tight packaging, and
wherein said liquid-tight packaging has at least one impervious seal whereby said impervious seal is facilitated by the release of said liquid phase consisting substantially of water that was released from the hydrous composition after a temporal delay;
the hydrous composition is a hydrogel based on a low-ester pectin or on a low-ester amidated pectin, and where the composition comprises as activating agent an alkaline earth or earth metal salt in an amount sufficient for the release of the liquid phase consisting substantially of water.