CPC A61K 9/1688 (2013.01) [A61K 9/1617 (2013.01); A61K 9/1623 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1694 (2013.01); F26B 5/005 (2013.01)] | 33 Claims |
1. A process for the continuous manufacture of amorphous solid dispersions or API alone particles comprising the steps of:
continuously feeding a suspension comprising at least one component and at least one solvent to at least one microfluidization device;
mixing the suspension in the microfluidization device by means of micro-reaction or microfluidization to produce a homogeneous spray solution;
feeding said spray solution in a continuous mode to a spray dryer;
atomizing said spray solution to produce droplets using at least one atomization nozzle; and
drying said droplets in a drying chamber to obtain particles.
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