US 11,752,105 B2
Spray drying process with continuous preparation of spray solution
João Vicente, Lisbon (PT); Clara Sá Couto, Amadora (PT); Rui Ferreira, Leiria (PT); and Marcio Temtem, Quinta do Conde (PT)
Assigned to Hovione Scientia Limited, Cork (IE)
Appl. No. 16/971,789
Filed by Hovione Scientia Limited, Cork (IE)
PCT Filed Feb. 22, 2019, PCT No. PCT/GB2019/050495
§ 371(c)(1), (2) Date Aug. 21, 2020,
PCT Pub. No. WO2019/162688, PCT Pub. Date Aug. 29, 2019.
Claims priority of application No. 110585 (PT), filed on Feb. 22, 2018.
Prior Publication US 2021/0077405 A1, Mar. 18, 2021
Int. Cl. A61K 9/16 (2006.01); F26B 5/00 (2006.01)
CPC A61K 9/1688 (2013.01) [A61K 9/1617 (2013.01); A61K 9/1623 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1694 (2013.01); F26B 5/005 (2013.01)] 33 Claims
OG exemplary drawing
 
1. A process for the continuous manufacture of amorphous solid dispersions or API alone particles comprising the steps of:
continuously feeding a suspension comprising at least one component and at least one solvent to at least one microfluidization device;
mixing the suspension in the microfluidization device by means of micro-reaction or microfluidization to produce a homogeneous spray solution;
feeding said spray solution in a continuous mode to a spray dryer;
atomizing said spray solution to produce droplets using at least one atomization nozzle; and
drying said droplets in a drying chamber to obtain particles.