| US 7,589,144 B2 | ||
| Granules obtained by drying a multiple emulsion | ||
| Hélène Lannibois-Drean, Charenton le Pont (France); Mikel Morvan, Princeton, N.J. (US); and Laurent Taisne, Paris (France) | ||
| Assigned to Rhodia Chimie, Cedex (France) | ||
| Filed on Jul. 20, 2006, as Appl. No. 11/490,339. | ||
| Application 11/490339 is a division of application No. 10/399653, filed on Aug. 11, 2003, granted, now 7,101,931. | ||
| Claims priority of application No. 00 13466 (FR), filed on Oct. 20, 2000. | ||
| Prior Publication US 2006/0258795 A1, Nov. 16, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 8/04 (2006.01); C08J 3/03 (2006.01) | ||
| U.S. Cl. 524—501 [524/502; 524/503; 524/505; 524/801; 516/54; 516/56] | 31 Claims |
| 1. A granule made by the process of drying an inverse emulsion, dispersed in an external aqueous phase, wherein:
(a) the inverse emulsion comprises an internal aqueous phase comprising at least one hydrophilic active substance, dispersed
in an internal organic phase, said inverse emulsion comprising at least one nonionic surfactant, at least one amphiphilic
block polymer, or at least one cationic surfactant; and
(b) the external aqueous phase comprises:
at least one polyalkoxylated nonionic surfactant or at least one polyalkoxylated amphiphilic nonionic polymer, and
at least one water-soluble or water-dispersible polymer,
wherein said at least one water-soluble or water-dispersible polymer:
is a solid in the presence of a water content of at most 10% by weight relative to the weight of said at least one water-soluble
or water-dispersible polymer, and
has a glass transition temperature of greater than 25° C.
|