US 7,588,900 B2
	Mammalian sweet and amino acid heterodimeric taste receptors
Charles S Zuker, San Diego, Calif. (US); Nicholas J. P. Ryba, Bethesda, Md. (US); Jayaram Chandrashekar, San Diego, Calif. (US); Mark A Hoon, Kensington, Md. (US); Yifeng Zhang, Boston, Mass. (US); and Greg Nelson, San Diego, Calif. (US)
Assigned to The Regents of the University of California, Oakland, Calif. (US); and The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, D.C. (US)
Filed on Jul. 03, 2002, as Appl. No. 10/190,417.
Application 10/190417 is a continuation in part of application No. 09/927315, filed on Aug. 10, 2001.
Claims priority of provisional application 60/302898, filed on Jul. 03, 2001.
Claims priority of provisional application 60/358925, filed on Feb. 22, 2002.
Prior Publication US 2003/0166137 A1, Sep. 04, 2003
Int. Cl. C07K 14/705 (2006.01); G01N 33/566 (2006.01)

U.S. Cl. 435—7.21  [435/69.1; 435/252.3; 435/320.1; 436/501]

29 Claims

1. An isolated taste receptor, wherein the receptor comprises a T1R3 polypeptide and a heterologous polypeptide, wherein the T1R3 polypeptide, has at least 93% amino acid sequence identity to SEQ ID NO:20 or has at least 94% amino acid sequence identity to SEQ ID NO:23 and the heterologous polypeptide is a T1R1 polypeptide that is at least 90% identical to an amino acid sequence of SEQ ID NO:2.