| US 7,588,794 B2 | ||
| Coatings for drug delivery devices based on poly (orthoesters) | ||
| Stephen D. Pacetti, San Jose, Calif. (US) | ||
| Assigned to Advanced Cardiovascular Systems, Inc., Santa Clara, Calif. (US) | ||
| Filed on Sep. 21, 2007, as Appl. No. 11/859,372. | ||
| Application 11/859372 is a continuation of application No. 10/382197, filed on Mar. 04, 2003, granted, now 7,288,609. | ||
| Prior Publication US 2008/0071027 A1, Mar. 20, 2008 | ||
| Int. Cl. A61F 2/06 (2006.01); A61F 2/00 (2006.01); C08G 2/00 (2006.01); C08G 65/48 (2006.01); C08G 4/00 (2006.01) | ||
| U.S. Cl. 427—2.1 [427/2.24; 427/2.25; 525/54.21; 525/54.24; 525/58; 525/60; 525/63; 525/88; 525/92 A; 525/92 L; 525/410; 525/415; 525/418; 525/419; 525/420; 525/434; 525/437; 525/439; 525/450; 525/453; 525/454; 525/474; 525/479; 623/1.15; 623/1.39] | 23 Claims |
| 1. A coating for a medical device comprising: a block copolymer and another polymer, wherein the block copolymer has
a first block comprising a soft segment having a Tg below 37° C. wherein the soft segment is a reaction product of a spirodiketene acetal and a non-fouling moiety selected from
the group consisting of a poly(alkylene glycol), poly(ethylene oxide-co-propylene oxide) (PLURONIC®), hydroxylated poly(vinyl
pyrrolidone), dextran, dextrin, hyaluronic acid and derivatives thereof, poly(2-hydroxyethyl methacrylate) and mixtures thereof;
and,
a second block comprising a hard segment having a Tg above 37° C. wherein the hard segment is a reaction product of a spirodiketene acetal and a diol selected from the group consisting
of a C2-C16 alkylene glycol, a cycloaliphatic diol, a cyclohexanedimethanol, an oligoalkylene glycol.
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