| US 7,588,781 B2 | ||
| Method for increasing bioavailability of lipophilic bioactive compounds | ||
| Karlheinz Bortlik, Savigny (Switzerland); Francoise Saucy, Blonay (Switzerland); Eliane Duruz, Epalinges (Switzerland); Myriam Richelle, Savigny (Switzerland); Pierre Lambelet, Saint-Legier (Switzerland); Markus Baur, Aran (Switzerland); and Andrea M. A. Pfeifer, Saint-Legier (Switzerland) | ||
| Assigned to Nestec S.A., Vevey (Switzerland) | ||
| Filed on Oct. 27, 2006, as Appl. No. 11/553,847. | ||
| Application 11/553847 is a division of application No. 10/057660, filed on Jan. 25, 2002. | ||
| Application 10/057660 is a continuation in part of application No. PCT/EP01/06145, filed on May 29, 2001. | ||
| Claims priority of application No. 00111542 (EP), filed on May 30, 2000. | ||
| Prior Publication US 2007/0071830 A1, Mar. 29, 2007 | ||
| Int. Cl. A61K 9/00 (2006.01); A61K 35/20 (2006.01); A61K 36/00 (2006.01) | ||
| U.S. Cl. 424—535 [424/400; 424/520; 424/725; 424/755; 424/757] | 17 Claims |
| 1. A method for increasing bioavailability of a lipophilic bioactive compound to a subject upon administration, the method
comprising:
associating a whey protein with the lipophilic bioactive compound by dissolving the whey protein in water to form a first
solution, dissolving the lipophilic bioactive compound in a solvent to form a second solution, combining the first and second
solutions, and evaporating the solvent to form a primary composition as a dispersion, the whey protein present in an amount
sufficient to increase the bioavailability of the lipophilic bioactive compound to the subject upon administration; and
administering the primary composition to the subject, wherein increased amounts of the lipophilic bioactive compound are released
as compared to lipophilic compositions that do not include whey protein.
|