US 7,588,758 B2
	COX-2 function and wound healing
J. Patrick O'Connor, Fanwood, N.J. (US)
Assigned to University of Medicine and Dentistry of New Jersey, Somerset, N.J. (US)
Filed on Sep. 11, 2001, as Appl. No. 9/953,067.
Prior Publication US 2003/0082141 A1, May 01, 2003
Int. Cl. A61K 38/44 (2006.01); C12N 9/02 (2006.01); C12P 21/04 (2006.01); C12N 1/20 (2006.01); C07H 21/04 (2006.01)

U.S. Cl. 424—94.4  [435/189; 435/69.1; 435/71.1; 435/252.3; 536/23.2]

12 Claims

1. A method for treating a wound comprising the step of administering continuously for at least two weeks a therapeutically effective amount of a composition comprising a formulated cyclooxygenase-2 (COX-2) protein having the amino acid sequence of SEQ ID NO:4 to a patient with a skin, tendon, ligament, or bone wound so that COX-2 activity is increased.