| US 7,588,752 B2 | ||
| Antimicrobial peptides | ||
| Eric C. Reynolds, North Balwyn (Australia); Stuart G. Dashper, Hawthorn (Australia); Neil M. O'Brien-Simpson, Brunswick (Australia); Gert H. Talbo, Viewbank (Australia); and Marina Malkoski, Nunawading (Australia) | ||
| Assigned to The University of Melbourne, Parkville, Victoria (Australia) | ||
| Filed on Oct. 24, 2002, as Appl. No. 10/280,833. | ||
| Application 10/280833 is a continuation of application No. 09/554997, abandoned, previously published as PCT/AU98/00972, filed on Nov. 24, 1998. | ||
| Claims priority of application No. PP0514 (AU), filed on Nov. 24, 1997. | ||
| Prior Publication US 2003/0195150 A1, Oct. 16, 2003 | ||
| Int. Cl. A61Q 11/00 (2006.01); A61K 35/20 (2006.01); A23J 3/10 (2006.01) | ||
| U.S. Cl. 424—49 [530/300; 530/360] | 25 Claims |
| 1. A method of treating or prophylactically treating dental caries or periodontal disease in a subject, the method comprising
the step of administering a peptide to the teeth or gums of the subject in need of such treatment, wherein the peptide is
selected from:
a) a peptide consisting of the amino acid sequence AVESTVATLEASPEVIESPPE (SEQ ID NO:3), wherein serine at amino acid residue
12 of SEQ ID NO:3 is a phosphoseryl residue;
b) a peptide consisting of the amino acid sequence AVESTVATLEDSPEVIESPPE (SEQ ID NO:4), wherein serine at amino acid residue
12 of SEQ ID NO:4 is a phosphoseryl residue;
c) MAIPPKKNQDKTEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:8), wherein serine at amino acid residue 44
of SEQ ID NO:8 is a phosphoseryl residue;
d) a peptide consisting of the amino acid sequence MAIPPKKNQDKTEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID
NO:9), wherein serine at amino acid residue 22 and amino acid residue 44 of SEQ ID NO:9 are phosphoseryl residues;
e) MAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:10), wherein serine at amino acid residue 44
of SEQ ID NO:10 is a phosphoseryl residue;
f) MAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO: 11), wherein serine at amino acid residue
22 and amino acid residue 44 of SEQ ID NO:11 are phosphoseryl residues;
g) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:12), wherein
serine at amino acid residue 33 of SEQ ID NO:12 is a phosphoseryl residue;
h) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTIEAVESTVATLEASPEVIESPPEINTVQVTSTAV (SEQ ID NO:13), wherein
serine at amino acid residue 11 and serine at amino acid residue 33 of SEQ ID NO:13 are phosphoseryl residues;
i) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:14), wherein
serine at amino acid residue 33 of SEQ ID NO:14 is a phosphoseryl residue; and
j) a peptide consisting of the amino acid sequence TEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEINTVQVTSTAV (SEQ ID NO:15), wherein
serine at amino acid residue 11 and serine at amino acid residue 33 of SEQ ID NO:15 are phosphoseryl residues.
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