| US 7,586,021 B2 | ||
| Nucleic acid construct, metabolic disordered non-human animal and use thereof | ||
| Ko Fujimori, Ibaraki (Japan); and Koichi Saito, Takarazuka (Japan) | ||
| Assigned to Sumitomo Chemical Company, Limited, Tokyo (Japan) | ||
| Filed on May 11, 2006, as Appl. No. 11/431,891. | ||
| Claims priority of application No. 2005-138225 (JP), filed on May 11, 2005. | ||
| Prior Publication US 2006/0277617 A1, Dec. 07, 2006 | ||
| Int. Cl. A01K 67/027 (2006.01); A01K 67/00 (2006.01) | ||
| U.S. Cl. 800—18 [800/14; 800/8] | 4 Claims |
| 1. A transgenic mouse or its progeny or part thereof, which comprises in its genome a nucleic acid construct comprising a
polynucleotide encoding an isoform of human-derived liver X receptor α protein that comprises the amino acid sequence of SEQ
ID NO: 1:
wherein a liver-specific promoter is operably linked to the polynucleotide; and
wherein the LXRα protein is expressed in liver; and
wherein the mouse exhibits an increase in body weight and blood cholesterol compared to a wild-type mouse, after ingestion
of a high-fat diet.
|