| US 7,585,880 B2 | ||
| Phenylpropanoic acid derivatives | ||
| Tsuneo Yasuma, Osaka (Japan); Shinobu Sasaki, Osaka (Japan); and Nozomu Sakai, Osaka (Japan) | ||
| Assigned to Takeda Pharmaceutical Company Limited, Osaka (Japan) | ||
| Appl. No. 10/584,730 PCT Filed Dec. 24, 2004, PCT No. PCT/JP2004/019749 § 371(c)(1), (2), (4) Date Jun. 23, 2006, PCT Pub. No. WO2005/063725, PCT Pub. Date Jul. 14, 2005. |
||
| Claims priority of application No. 2003-435089 (JP), filed on Dec. 26, 2003. | ||
| Prior Publication US 2007/0155808 A1, Jul. 05, 2007 | ||
| Int. Cl. A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/427 (2006.01); A61K 31/422 (2006.01); C07D 277/22 (2006.01); C07D 263/32 (2006.01); C07D 417/10 (2006.01); C07D 413/10 (2006.01) | ||
| U.S. Cl. 514—340 [514/342; 514/365; 514/374; 546/268.7; 546/269.1; 548/146; 548/215] | 13 Claims |
1. A compound represented by the formula (I)
 wherein X is S or O,
R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted C6-14 aryl group, an optionally substituted heterocyclic group or an optionally substituted C1-6 alkyl group, or R1 and R2 are bonded to each other to form a ring together with the carbon atom they are bonded to,
E is —W1—N(R5)—W2—, —W1—CH(R6)—O—W2—, —W1—O—CH(R6)—W2—, —W1—S(O)n-W2— or —W1—CH(R6)—W2— (W1 and W2 are the same or different and each is a bond or an optionally substituted C1-3 alkylene group, R5 and R6 are each an optionally substituted heterocyclic group or an optionally substituted hydrocarbon group, and n is 1 or 2, provided
that when X is S, then R5 and R6 are not C1-6 alkyl groups),
ring S1 is a benzene ring or pyridine ring each optionally further having substituent(s) selected from an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group and a halogen atom,
R3 and R4 are the same or different and each is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group or an optionally substituted C1-6 alkoxy group,
R9 and R10 are the same or different and each is a hydrogen atom, a halogen atom or a C1-6 alkoxy group, and
R is an optionally substituted hydroxy group or an optionally substituted amino group, or a prodrug or a salt thereof.
|