| US 7,585,848 B2 | ||
| Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc | ||
| Koichi Masuda, Wilmette, Ill. (US); and Takefumi Gemba, Kawanishi (Japan) | ||
| Assigned to Rush University Medical Center, Chicago, Ill. (US); and Anges MG, Inc., Osaka (Japan) | ||
| Filed on Jan. 11, 2005, as Appl. No. 11/33,466. | ||
| Prior Publication US 2006/0153847 A1, Jul. 13, 2006 | ||
| Int. Cl. A61K 31/70 (2006.01); C07H 21/04 (2006.01) | ||
| U.S. Cl. 514—44 [536/23.1; 536/24.5] | 9 Claims |
| 1. A method for the treatment of intervertebral disc degeneration, comprising:
administration of a NF-κB inhibitor into an intervertebral disc wherein administration of the NF-κB inhibitor treats an intervertebral
disc degeneration, and wherein the NF-κB inhibitor is selected from the group consisting of: a decoy oligonucleotide capable
of binding to the DNA binding site of NF-κB, an antisense NF-κB nucleic acid, and a NF-κB siRNA, and further wherein the NF-κB
inhibitor acts directly on NF-κB, or directly on NF-κB mRNA.
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