| US 7,585,519 B2 | ||
| Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds | ||
| Claudio Pisano, Aprilia (Italy); Maria Ornella Tinti, Rome (Italy); Mosé Santaniello, Nettuno (Italy); Luciana Critelli, Pomezia (Italy); and Giovanni Salvatori, Rome (Italy) | ||
| Assigned to Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Rome (Italy) | ||
| Filed on Mar. 27, 2007, as Appl. No. 11/727,526. | ||
| Application 11/727526 is a division of application No. 10/624645, filed on Jul. 23, 2003. | ||
| Application 10/624645 is a division of application No. 09/958328, filed on Oct. 09, 2001, granted, now 6,797,281, filed on Sep. 28, 2004. | ||
| Claims priority of application No. RM99A0220 (IT), filed on Apr. 13, 1999; and application No. PCT/IT00/00137 (IT), filed on Nov. 04, 2000. | ||
| Prior Publication US 2007/0190128 A1, Aug. 16, 2007 | ||
| Int. Cl. A61K 9/127 (2006.01) | ||
| U.S. Cl. 424—450 [424/434; 424/435; 424/449; 424/43] | 9 Claims |
1. A method of transporting a naturally occurring or modified plasmid or polynucleotide to the liver, lung or heart using
a liposome containing a compound of formula (III):
 where:
R5 is selected from the group consisting of nonanoyl, dodecanoyl, myristoyl, palmitoyl, stearoyl or oleoyl;
R6 is undecyl; and
the molar ratio between the compound of formula (III) and the plasmid or polynucleotide is 12:1.
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