US 11,739,174 B2
Cationic cyclic amine and amphipathic transfection reagents
Nicholas A. A. Rossi, Madison, WI (US); Anatoly Pinchuk, Fitchburg, WI (US); Karen Neder, Madison, WI (US); James Ludtke, Madison, WI (US); and Laura Juckem, Madison, WI (US)
Assigned to Mirus Bio LLC, Madison, WI (US)
Filed by Mirus Bio LLC, Madison, WI (US)
Filed on Feb. 21, 2020, as Appl. No. 16/797,967.
Application 16/797,967 is a continuation of application No. 14/632,385, filed on Feb. 26, 2015, granted, now 10,619,162, issued on Apr. 14, 2020.
Prior Publication US 2021/0269570 A1, Sep. 2, 2021
Prior Publication US 2022/0041778 A9, Feb. 10, 2022
Int. Cl. C08F 226/06 (2006.01); C07D 241/04 (2006.01); C12N 15/87 (2006.01)
CPC C08F 226/06 (2013.01) [C07D 241/04 (2013.01); C12N 15/87 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A composition for delivery of a nucleic acid into a cell comprising:
(i) a polymer comprising a first cyclic amine; and
(ii) an amphipathic compound comprising a second cyclic amine;
wherein said polymer is different from said amphipathic compound.