CPC B01L 3/502715 (2013.01) [C12M 23/16 (2013.01); G01N 33/5058 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0858 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/123 (2013.01); G01N 2570/00 (2013.01)] | 14 Claims |
1. A microphysiological system (MPS), comprising:
at least one first inlet for receiving a fluid medium;
a brain module comprising brain tissue;
a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium; and
a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module, the bidirectional crosstalk configured for exchange of one or more of nutrients, signaling molecules, and drugs between the brain module and the BBB module.
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