US 11,738,340 B2
Neurodegenerative target discovery platform
Murat Cirit, Cambridge, MA (US); Begum Alaybeyoglu, Cambridge, MA (US); Jason Samuel Sherfey, Somerville, MA (US); John Wayne Rumsey, Somerville, MA (US); and Yoojin Shin, Burlington, MA (US)
Assigned to Javelin Biotech, Inc., Woburn, MA (US)
Filed by Javelin Biotech, Inc., Woburn, MA (US)
Filed on Oct. 5, 2020, as Appl. No. 17/63,073.
Claims priority of provisional application 63/034,260, filed on Jun. 3, 2020.
Claims priority of provisional application 62/910,996, filed on Oct. 4, 2019.
Prior Publication US 2021/0101146 A1, Apr. 8, 2021
Int. Cl. C12N 15/10 (2006.01); B01L 3/00 (2006.01); G01N 21/3504 (2014.01); G01N 33/00 (2006.01); G01N 33/574 (2006.01); G01N 21/64 (2006.01); A61K 45/06 (2006.01); G01N 21/35 (2014.01); G01N 33/50 (2006.01); G01N 33/543 (2006.01); B01L 3/02 (2006.01); G01N 33/53 (2006.01); C12M 3/06 (2006.01)
CPC B01L 3/502715 (2013.01) [C12M 23/16 (2013.01); G01N 33/5058 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0858 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/123 (2013.01); G01N 2570/00 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A microphysiological system (MPS), comprising:
at least one first inlet for receiving a fluid medium;
a brain module comprising brain tissue;
a blood-brain-barrier (BBB) module comprising BBB tissue, the BBB module configured to receive the fluid medium; and
a crosstalk channel between the brain module and the BBB module, the crosstalk channel configured to promote a bidirectional crosstalk between the brain tissue and the BBB tissue in response to receiving the fluid medium at the BBB module, the bidirectional crosstalk configured for exchange of one or more of nutrients, signaling molecules, and drugs between the brain module and the BBB module.