| US 7,582,651 B2 | ||
| Pyrrolopyridine derivative and use thereof | ||
| Takahiro Matsumoto, Hyogo (Japan); Osamu Kurasawa, Nishinomiya (Japan); Tsuneo Oda, Ibaraki (Japan); Hiroshi Nagabukuro, Osaka (Japan); and Manabu Mochizuki, Suita (Japan) | ||
| Assigned to Takeda Pharmaceutical Company Limited, Osaka (Japan) | ||
| Appl. No. 10/520,784 PCT Filed Jul. 10, 2003, PCT No. PCT/JP03/08791 § 371(c)(1), (2), (4) Date Jan. 10, 2005, PCT Pub. No. WO2004/007495, PCT Pub. Date Jan. 22, 2004. |
||
| Claims priority of application No. 2002-202204 (JP), filed on Jul. 11, 2002. | ||
| Prior Publication US 2006/0167038 A1, Jul. 27, 2006 | ||
| Int. Cl. A61K 31/44 (2006.01); C07D 513/02 (2006.01) | ||
| U.S. Cl. 514—300 [546/113] | 8 Claims |
1. A compound represented by the formula
 wherein Ring A represents a pyridine ring which may have one or two C1-4 alkly groups, X represents a nitrile group, Y represents —CH═CH— or —(CH2)2, R1 represents (1) a C5-7 cycloalkyl group optionally fused with a benzene ring, (2) a C7-19 aralkyl group, (3) a 5- or 6-membered heterocyclic ring-C1-4 alkyl group or (4) a C6-14 aryloxy-C1-4 alkyl group, each of which may have 1 to 4 substituents selected from a halogen atom, a C1-4 alkyl group, a mono-, di- or tri-halogeno-C1-4 alkyl group and a C1-4 alkoxy group, and one of R2 and R3 is a hydrogen atom or a C1-4 alkyl group, and the other is a C6-14 aryl group, a C7-19 aralkyl group, a C3-10 cycloalkyl group, a tetrahydropyranyl group, a pyranyl group or a pyridyil group or a C1-6 alkyl group, each of which may have 1 to 4 substituents selected from a halogen atom, a C1-4 alkyl group, a mono-, di- or tri- halogeno-C1-4 alkyl group, a C1-4 alkoxy group, a C1-4 alkoxy-carbonyl group, a cyano group, a C1-4 alkyl-carbonylamino group and a hydroxyl group or a salt thereof.
|