US 7,579,507 B2
	Polymorphic crystal of 4′-{2-[ (1S, 2R)—2- hydroxy-2- (4-hydroxyphenyl)-1-methylethylamino]ethoxy} - 3 - isopropyl-3′, 5′ -dimethylbiphenyl- 4 - carboxylic acid hydrochloride
Kiyoshi Kasai, Niigata (Japan); Takehiro Ishikawa, Nagano (Japan); Tetsuji Ozawa, Niigata (Japan); Koji Kamata, Niigata (Japan); Ritsu Suzuki, Nagano (Japan); and Hideki Takeuchi, Nagano (Japan)
Assigned to Kissei Pharmaceutical Co., Ltd., Matsumoto-Shi (Japan)
Filed on Oct. 12, 2007, as Appl. No. 11/871,710.
Application 11/871710 is a continuation in part of application No. PCT/JP2006/308267, filed on Apr. 20, 2006.
Claims priority of application No. 2005-125289 (JP), filed on Apr. 22, 2005; and application No. 2006-279978 (JP), filed on Oct. 13, 2006.
Prior Publication US 2008/0076826 A1, Mar. 27, 2008
Int. Cl. C07C 217/14 (2006.01)

U.S. Cl. 568—585  [568/586; 562/405; 562/442; 514/567; 514/646]

3 Claims

1. A crystal of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3′,5′-dimethylbiphenyl-4-carboxylic acid hydrochloride wherein its diffraction pattern by the powder X-ray diffractometry has characteristic peaks at diffraction angles (2θ) of 6.22, 8.60, 12.2, 15.4, 17.8, 18.2, 18.8, 20.5 and 23.4°.