US 7,579,479 B2
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
Peter T. Cheng, Princeton, N.J. (US); Pratik Devasthale, Plainsboro, N.J. (US); Yoon Jeon, Belle Mead, N.J. (US); Sean Chen, Princeton, N.J. (US); and Hao Zhang, Belle Mead, N.J. (US)
Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US)
Filed on Aug. 22, 2005, as Appl. No. 11/155,965.
Application 11/155965 is a division of application No. 10/655876, filed on Sep. 05, 2003, granted, now 7,084,162.
Application 10/655876 is a division of application No. 10/080981, filed on Feb. 22, 2002, granted, now 6,653,314.
Application 10/080981 is a continuation of application No. 09/812960, filed on Mar. 20, 2001, granted, now 6,414,002.
Application 09/812960 is a continuation in part of application No. 09/664598, filed on Sep. 18, 2000, abandoned.
Claims priority of provisional application 60/155400, filed on Sep. 22, 1999.
Prior Publication US 2007/0015797 A1, Jan. 18, 2007
Int. Cl. C07D 263/34 (2006.01)
U.S. Cl. 548—236 9 Claims
 
1. A compound having the structure

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing

OG Complex Work Unit Drawing
wherein PG in amino ester (a) and carbamoyl chloride (c) is a carboxylic acid protecting group, and

OG Complex Work Unit Drawing
wherein X1x is an alkylene chain of 1 to 4 carbons, an alkenylene chain of 2 to 4 carbons or an alkynylene chain of 2 to 4 carbons;
X1m is an alkylene chain of 1 or 2 carbons, an alkenylene chain of 2 carbons or an alkynylene chain of 2 carbons;
X1n is an alkylene chain of 1 or 2 carbons, an alkenylene chain of 2 carbons or an alkynylene chain of 2 carbons;
Q is C;
A is O;
R1 is H or lower alkyl;
X is CH
R2 is H, alkyl, alkoxy, halogen, amino or substituted amino;
R2a, R2b and R2c are the same or different and are selected from H, alkyl alkoxy, halogen, amino or substituted amino;
or stereoisomers thereof, or a pharmaceutically acceptable salt thereof.