| US 7,579,466 B2 | ||
| Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by VLA-4 | ||
| Jenifer Smith, South San Francisco, Calif. (US); Christopher Semko, Fremont, Calif. (US); Ying-Zi Xu, Palo Alto, Calif. (US); and Andrei W. Konradi, Burlingame, Calif. (US) | ||
| Assigned to Elan Pharmaceuticals, Inc., South San Francisco, Calif. (US) | ||
| Filed on Feb. 26, 2007, as Appl. No. 11/679,042. | ||
| Claims priority of provisional application 60/777595, filed on Feb. 27, 2006. | ||
| Prior Publication US 2008/0058357 A1, Mar. 06, 2008 | ||
| Int. Cl. C07D 239/50 (2006.01); C07D 403/12 (2006.01); A61K 31/506 (2006.01); A61P 19/02 (2006.01) | ||
| U.S. Cl. 544—323 [544/324; 544/325; 514/275] | 32 Claims |
1. A compound of formula I:
 wherein:
R1 is selected from the group consisting of C1 to C4 alkyl and C1 to C4 haloalkyl; and
R2 is selected from the group consisting of C1 to C4 alkyl, C2 to C4 alkenyl, C2 to C4 alkynyl, and C3-C6 cycloalkyl;
or a pharmaceutically acceptable salt thereof;
or an ester thereof, wherein the ester is an ester of the —COOH group.
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