US 7,579,464 B2
Process for preparation of enantiomerically pure compounds
Fabienne Hoffmann-Emery, Weil am Rhein (Germany); and Roland Jakob-Roetne, Inzlingen (Germany)
Assigned to Hoffmann-La Roche Inc., Nutley, N.J. (US)
Filed on Apr. 28, 2008, as Appl. No. 12/110,372.
Claims priority of application No. 07108904 (EP), filed on May 25, 2007.
Prior Publication US 2008/0293933 A1, Nov. 27, 2008
Int. Cl. C07D 223/18 (2006.01)
U.S. Cl. 540—522 13 Claims
 
1. A process for the preparation of an enantiomerically pure 7-amino-5H,7H-dibenzo[b,d]azepin-6-one of the formula Ia,

OG Complex Work Unit Drawing
wherein R1 is hydrogen or halogen, comprising the optical resolution of a dibenzo[b,d]azepinone derivative of the formula II,

OG Complex Work Unit Drawing
wherein R1 is as in the compound of formula Ia and R2 is either C1-4-alkyl optionally substituted with cycloalkyl or benzyl which is optionally substituted with C1-4-alkoxy, using a chiral menthyl chloroformate.