| US 7,579,449 B2 | ||
| Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture | ||
| Matthias Eckhardt, Biberach (Germany); Peter Eickelmann, Mittelbiberach (Germany); Frank Himmelsbach, Mittelbiberach (Germany); Edward Leon Barsoumian, Toyonaka (Japan); and Leo Thomas, Biberach (Germany) | ||
| Assigned to Boehringer Ingelheim International GmbH, Ingelheim (Germany) | ||
| Filed on Mar. 15, 2005, as Appl. No. 11/80,150. | ||
| Claims priority of provisional application 60/560239, filed on Apr. 07, 2004. | ||
| Claims priority of application No. 10 2004 012 676 (DE), filed on Mar. 16, 2004; application No. 10 2004 040 168 (DE), filed on Aug. 18, 2004; application No. 10 2004 061 145 (DE), filed on Dec. 16, 2004; and application No. 05002628 (EP), filed on Feb. 09, 2005. | ||
| Prior Publication US 2005/0209166 A1, Sep. 22, 2005 | ||
| Int. Cl. A61K 31/70 (2006.01); A61K 31/7004 (2006.01); A61K 31/351 (2006.01); C07H 7/04 (2006.01); C07H 309/10 (2006.01) | ||
| U.S. Cl. 536—1.11 [514/23; 514/460; 549/417] | 25 Claims |
1. Glucopyranosyl-substituted benzene derivatives of general formula I.2c
 R1 is selected from hydrogen, fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, ethynyl, hydroxy, methoxy, ethoxy,
cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, and
R2 is hydrogen, fluorine, hydroxy, methoxy, ethoxy or methyl, and
R3 is selected from trimethylsilylethyl, ethynyl, 2-hydroxyprop-2-ylethynyl, 2-methoxyprop-2-ylethynyl, 3-hydroxy-1-propyn-1-yl,
3-methoxy-1-propyn-1-yl, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy,
piperidin-4-yloxy, N-methylpiperidin-4-yloxy and N-acetylpiperidin-4-yloxy, and
R4, R5 independently of one another is hydrogen or fluorine, and
R6 is hydrogen, (C1-6-alkyl)carbonyl or (C1-6-alkyl)oxycarbonyl, and
R7a, R7b and R7c are hydrogen,
while, unless otherwise stated, the above-mentioned alkyl groups may be straight-chain or branched,
the stereoisomers thereof, the mixtures thereof and the salts thereof.
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