US 7,579,444 B2
	Polymer-factor IX moiety conjugates
Mary J. Bossard, Madison, Ala. (US); and Gayle Stephenson, Decatur, Ala. (US)
Assigned to Nektar Therapeutics AL, Corporation, Huntsville, Ala. (US)
Filed on Jun. 30, 2005, as Appl. No. 11/172,459.
Claims priority of provisional application 60/584505, filed on Jun. 30, 2004.
Prior Publication US 2006/0052302 A1, Mar. 09, 2006
Int. Cl. C07K 14/745 (2006.01)

U.S. Cl. 530—384  [530/402; 530/324; 530/345; 514/2]

18 Claims

1. A conjugate comprising a Factor IX moiety covalently attached, either directly or through a spacer moiety comprised of one or more atoms, to at least one nonpeptidic, water-soluble polymer, wherein (i) the at least one nonpeptidic, water-soluble polymer has a total weight-average molecular weight in the range of from greater than 10,000 Daltons to about 85,000 Daltons, (ii) when the Factor IX moiety is covalently attached through a spacer moiety comprised of one or more atoms to the at least one nonpeptidic, water-soluble polymer, the spacer moiety does not include a sugar or carbohydrate, and (iii) not more than three nonpeptidic, water-soluble polymers are attached to the Factor IX moiety.