US 7,579,167 B2
Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
Marie-Helene Blondelet-Rouault, Orsay (France); Helene Dominguez, Avignon (France); Emmanuelle Darbon-Rongere, Voisins le Bretonneux (France); Claude Gerbaud, Gagny (France); Anne Gondran, Paris (France); Fatma Karray, Bures sur Yvette (France); Patricia Lacroix, Le Perreux (France); Nathalie Oestreicher-Mermet-Bouvier, Clamart (France); Pernodet Jean-Luc, Cachan (France); and Karine Tuphile, Caluire (France)
Assigned to Aventis Pharma S., Antony (France); and Centre National de la Recherche Scientifique, Paris (France)
Filed on Oct. 07, 2003, as Appl. No. 10/680,860.
Claims priority of provisional application 60/493490, filed on Aug. 07, 2003.
Claims priority of application No. 02 12489 (FR), filed on Oct. 08, 2002; and application No. 03 02439 (FR), filed on Feb. 27, 2003.
Prior Publication US 2005/0202528 A1, Sep. 15, 2005
Int. Cl. C12P 21/06 (2006.01)
U.S. Cl. 435—69.1  [435/6; 435/320.1; 435/325; 435/252; 530/350] 19 Claims
 
1. An isolated polynucleotide that encodes a polypeptide of the spiramycin biosynthesis pathway, wherein said polypeptide comprises the amino acid sequence SEQ ID NO:112 or 142.