| US 7,579,013 B2 | ||
| Formulations for coated microprojections containing non-volatile counterions | ||
| Mahmoud Ameri, Fremont, Calif. (US); WeiQi Lin, Palo Alto, Calif. (US); Michel J. N. Cormier, Mountain View, Calif. (US); and Yuh-Fun Maa, Millbrae, Calif. (US) | ||
| Assigned to Alza Corporation, Mountain View, Calif. (US) | ||
| Filed on Jun. 29, 2004, as Appl. No. 10/880,702. | ||
| Claims priority of provisional application 60/484020, filed on Jun. 30, 2003. | ||
| Prior Publication US 2004/0265354 A1, Dec. 30, 2004 | ||
| Int. Cl. A61K 9/00 (2006.01); C07K 14/00 (2006.01) | ||
| U.S. Cl. 424—400 [514/2; 530/300] | 15 Claims |
| 1. A composition comprising a formulation of a pharmaceutically active agent, a volatile counterion and a non-volatile counterion, wherein said pharmaceutically active agent is hPTH(1-34) present as uncharged species and as charged species and wherein said non-volatile counterion is present in an amount sufficient to achieve a molar ratio between said uncharged species and charged species of about 1 uncharged species to at least 100 charged species; wherein said formulation has increased pH stability and solubility when dried, and wherein said composition is applied to a transdermal delivery device having stratum corneum-piercing microprojections; wherein said composition achieves an increase in delivery of the pharmaceutically active agent compared to a composition comprising a formulation without said non-volatile counterion. |