	US 7,579,007 B2
	Production of “biological carriers” for induction of immune responses and inhibition of viral replication
Joseph D. Mosca, Ellicott City, Md. (US)
Assigned to JDM Technologies, Inc., Ellicott City, Md. (US)
Appl. No. 10/468,047 PCT Filed Feb. 12, 2002, PCT No. PCT/US02/04157 § 371(c)(1), (2), (4) Date Aug. 13, 2003, PCT Pub. No. WO02/079396, PCT Pub. Date Oct. 10, 2002.
Claims priority of provisional application 60/268066, filed on Feb. 13, 2001.
Prior Publication US 2004/0116367 A1, Jun. 17, 2004
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); C12N 7/04 (2006.01); C12P 21/00 (2006.01); C12N 15/09 (2006.01)

U.S. Cl. 424—204.1 [435/69.1; 435/69.3; 435/235.1; 435/236; 435/239; 424/184.1; 424/208.1]

16 Claims

1. A non-infectious biological carrier comprising a Human Immunodeficiency Virus (HIV) viral or viral-like particle that

(i) presents at least one exogenous antigen incorporated into said particle such that said at least one antigen initiates an immune response;

(ii) also expresses at least one exogenous antigen fragment bound to a primary host cell surface molecule selected from MHC I and MHC II; and

(iii) also expresses at least one B7 molecule as a co-stimulatory molecule.