| US 7,579,006 B2 | ||
| Method of treating immune pathologies with low dose estrogen | ||
| Halina Offner, Portland, Oreg. (US) | ||
| Assigned to Oregon Health and Science University, Portland, Oreg. (US); and The United States of America as represented by the Department of Veterans Affair, Washington, D.C. (US) | ||
| Filed on Apr. 03, 2008, as Appl. No. 12/62,476. | ||
| Application 12/062476 is a division of application No. 10/275833, granted, now 7,371,385, previously published as PCT/US01/40710, filed on May 11, 2001. | ||
| Claims priority of provisional application 60/203980, filed on May 12, 2000. | ||
| Prior Publication US 2008/0227761 A1, Sep. 18, 2008 | ||
| Int. Cl. A61K 39/38 (2006.01); A61K 39/00 (2006.01) | ||
| U.S. Cl. 424—198.1 [424/184.1] | 16 Claims |
| 1. A method of ameliorating a Th1-mediated immune pathology in a human subject, comprising
administering a dose of estrogen to said human subject sufficient to raise the serum concentration of estrogen in said human
to within the range from 30 pg/ml to 1000 pg/ml; and
administering a therapeutically effective amount of a glatiramer acetate to said human subject
thereby ameliorating the Th1-mediated immune pathology in said human subject, wherein the Th1-mediated immune pathology is
multiple sclerosis.
|