US 7,414,132 B2
Opioid receptor antagonists
Marta Garcia De La Torre, Alcobendas Madrid (Spain); Nuria Diaz Buezo, Alcobendas Madrid (Spain); Prabhakar Kondaji Jadhav, Zionsville, Ind. (US); Charles Howard Mitch, Columbus, Ind. (US); and Concepcion Pedregal-Tercero, Alcobendas Madrid (Spain)
Assigned to Eli Lilly and Company, Indianapolis, Ind. (US)
Appl. No. 10/581,178
PCT Filed Dec. 15, 2004, PCT No. PCT/US2004/039766
§ 371(c)(1), (2), (4) Date May 31, 2006,
PCT Pub. No. WO2005/066164, PCT Pub. Date Jul. 21, 2005.
Claims priority of application No. 03380303 (EP), filed on Dec. 22, 2003.
Prior Publication US 2007/0112036 A1, May 17, 2007
Int. Cl. C07D 213/00 (2006.01); C07D 231/56 (2006.01); C07D 261/20 (2006.01); C07D 413/00 (2006.01); C07D 498/00 (2006.01)
U.S. Cl. 546—1  [548/241; 548/361.1] 2 Claims
 
1. A compound selected from the group consisting of:
6-{4-[(3-Methyl-butylamino)-methyl]-phenoxy}-nicotinimidic acid ethyl ester

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N-Hydroxy-6-{4-[(3-methyl-butylamino)-methyl]-phenoxy}-nicotinamidine

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6-{4-[(3-Methyl-butylamino)-methyl]-phenoxy}-nicotinamidine

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{4-[5-(4,5-Dihydro-1H-imidazol-2-yl)-pyridin-2-yloxy]-benzyl}-(3-methyl-butyl)-amine

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{4-[5-(4,5-Dihydro-1H-imidazol-2-yl)-pyridin-2-yloxy]-benzyl}-(2-thiophen-2yl-ethyl)amine

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(3-Methyl-butyl)-{4-[5-(4,5,6,7-tetrahydro-1H-[1,3]diazepin-2-yl)-pyridin-2-yloxy]-benzyl}-amine

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(3-Methyl-butyl)-{4-[5-(1,4,5,6-tetrahydropyrimidin-2-yl)-pyridin-2-yloxy]-benzyl}-amine

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N-Cyano-6-{4-[(3-methyl-butylamino)-methyl]-phenoxy}-nicotinamidine

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(3-Methyl-butyl)-{4-[5-(2H-tetrazol-5-yl)-pyridin-2-yloxy]-benzyl}-amine

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{4-[5-(1H-Imidazol-2-yl)-pyridin-2-yloxy]-benzyl}-(3-methyl-butyl)-amine

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N-(2,2-Dimethoxy-ethyl)-6-{4-[(3-methyl-butylamino)-methyl]-phenoxy}-nicotinamidine

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6-{4-[3-Methyl-butylamino)-methyl]-phenoxy}-benzoisoxazol-3-ylamine

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6-{4-[(3,3-Dimethyl-butylamino)-methyl]-phenoxy}-benzo[d]isoxazol-3-ylamine

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6-(4-{[2-(4-Fluoro-phenyl-ethylamino]-methyl}-phenoxy)-benzo[d]isoxazol-3-ylamine

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6-(4-{[2-(Tetrahydro-pyran-4-yl)-ethylamino]-methyl}-phenoxy)-benzo[d]isoxazol-3-ylamine

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6-{4-[(3-Methyl-butylamino)-methyl]-phenoxy}-1H-indazol-3-ylamine

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or a pharmaceutically acceptable salt thereof.