| US 7,413,870 B2 | ||
| SAK: modulation of cellular proliferation for treatment of cancer | ||
| Yasumichi Hitoshi, Mountain View, Calif. (US); Susan Demo, Sunnyvale, Calif. (US); and Yonchu Jenkins, San Francisco, Calif. (US) | ||
| Assigned to Rigel Pharmaceuticals, Incorporated, South San Francisco, Calif. (US) | ||
| Filed on Dec. 21, 2001, as Appl. No. 10/26,021. | ||
| Claims priority of provisional application 60/309632, filed on Aug. 01, 2001. | ||
| Prior Publication US 2003/0027756 A1, Feb. 06, 2003 | ||
| Int. Cl. C12Q 1/50 (2006.01) | ||
| U.S. Cl. 435—15 | 9 Claims |
| 1. A method for identifying a compound that modulates cellular proliferation, the method comprising the steps of:
(i) contacting the compound with a SAK polypeptide, the polypeptide encoded by a nucleic acid that encodes the SAK polypeptide
of SEQ ID NO:2, the polypeptide having serine/threonine kinase activity; and
(ii) determining a functional effect of the compound upon the SAK polypeptide, wherein the functional effect is in vitro determined
by measuring kinase activity of the SAK polypeptide, which indicates that the compound modulates cellular proliferation.
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