US 7,576,255 B2
	Silver-containing compositions, devices, and methods for making
Bruce L. Gibbins, Lake Oswego, Oreg. (US); and Lance D. Hopman, Tigard, Oreg. (US)
Assigned to AcryMed, Inc., Beaverton, Oreg. (US)
Filed on Nov. 01, 2004, as Appl. No. 10/978,556.
Application 10/978556 is a continuation of application No. 10/441275, filed on May 19, 2003, granted, now 6,897,349.
Application 10/441275 is a continuation of application No. 09/675892, filed on Sep. 29, 2000, granted, now 6,605,751.
Application 09/675892 is a continuation of application No. 09/191223, filed on Nov. 13, 1998, granted, now 6,355,858.
Application 09/191223 is a continuation of application No. 08/971074, filed on Nov. 14, 1997, granted, now 5,928,174.
Claims priority of provisional application 60/212455, filed on Jun. 19, 2000.
Claims priority of provisional application 60/157000, filed on Oct. 01, 1999.
Prior Publication US 2005/0226931 A1, Oct. 13, 2005
Int. Cl. A61F 13/00 (2006.01)

U.S. Cl. 602—48  [602/43; 604/289; 604/304; 424/423; 424/445; 424/617; 424/619; 424/630]

9 Claims

1. A method for administering at least one active agent to tissue comprising applying a biocompatible hydrophilic polymeric matrix to tissue, wherein the biocompatible hydrophilic polymeric matrix comprises a hydrophilic cross-linked polymer network, and a metal colloid directly incorporated in the matrix, wherein the metal colloid is formed by the direct reaction of an anion and a metal cation, and wherein the anion is in an excess concentration of the metal cations, such that association of the metal cation and the anion is favored; and at least one active agent.